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Statins broader effects, including their ability to reduce systemic inflammation and biomarkers associated with poor ICI response (such as IL-6 and C-reactive protein [CRP]), further complicate the picture

FIGURE 2 TIRAP (toll/interleukin-1 receptor domain-containing adapter protein) recruits MyD88 (myeloid differentiation factor 88) directly to the TLR4 cytoplasmic domain

Topical calcipotriol plus oral fumaric acid is more effective and faster acting than oral fumaric acid monotherapy in the treatment of severe chronic plaque psoriasis vulgaris

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